Thermo Fisher Scientific ALKBH2 Polyclonal Antibody
Thermo Fisher Scientific의 ALKBH2 Polyclonal Antibody는 인간 ALKBH2 단백질을 인식하는 토끼 다클론 항체입니다. ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS와 글리세롤 기반의 액상 형태로 제공되며, 연구용으로 적합합니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human ALKBH2. Recombinant protein control fragment (Product #RP-106366) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2663676 |
Product Specific Information
Immunogen sequence:
LVKGAQGGLLR KQEEQEPTGE EPAVLGGDKE STRKRPRREA PGNGGHSAGP SWRHIRAEGL DCSYTVLFGK AE
- Highest antigen sequence identity to orthologs: mouse 37%, rat 40%
Target Information
The E. coli AlkB protein protects against the cytotoxicity of methylating agents by repairing specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 are mammalian homologs of AlkB that catalyze the removal of 1-methyladenine and 3-methylcytosine, modifications that, if left unchecked, could lead to cancerous cells.
Mutations in both ALKBH2 and ALKBH3 have been observed in pediatric brain tumors, indicating that these proteins are important in the prevention of cancer formation.
Like the histone demethylase JMJD1A, ALKBH2 is a non-heme iron enzyme inhibited by Nickel ions, suggesting that inhibition of ALKBH2 by Nickel ions may play a role in cancer development.
Conversely, ALKBH2 mRNA and protein levels are increased in glioma cells following Photofrin-mediated photodynamic therapy, suggesting that down-regulating ALKBH2 expression in cancer cells may enhance the anti-cancer effectiveness of this treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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