Thermo Fisher Scientific PD-1 (CD279) Chimeric Recombinant Rabbit Monoclonal Antibody (J43)
Thermo Fisher Scientific의 PD-1 (CD279) 키메릭 재조합 토끼 단클론 항체(J43)는 마우스 PD-1 특이적 항체로 다양한 면역학적 분석에 사용됩니다. WB, IHC, ICC/IF, Flow, ELISA 등 다중 응용 가능하며, 고순도 Protein A 정제 및 안정적 보관 조건을 제공합니다.
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Thermo Fisher Scientific PD-1 (CD279) Chimeric Recombinant Rabbit Monoclonal Antibody (J43)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.003 µg/mL |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 1:100 |
| ELISA | 10,000 ng/mL |
| Immunoprecipitation (IP) | Assay-dependent |
| Neutralization (Neu) | Assay-dependent |
| Functional Assay | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG, lambda |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | J43 |
| Immunogen | This antibody was raised by immunising Armenian hamsters with B12 cells, a PD-1 cDNA transfectant of BHK cells. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074678 |
Product Specific Information
Specificity: This antibody is specific for murine PD-1.
Target Information
Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is self-limited as activated T cells express receptors such as PD-1 (PDCD-1) that mediate inhibitory signals from APCs.
PD-1 binds to two related ligands, PDL-1 and PDL-2. Upon ligand binding, PD-1 signaling inhibits immune activation in the absence of danger signals (e.g., LPS or bacterial molecules).
PD1-deficient mice exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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