Thermo Fisher Scientific PD-1 (CD279) Chimeric Recombinant Rabbit Monoclonal Antibody (J43)

Thermo Fisher Scientific PD-1 (CD279) Chimeric Recombinant Rabbit Monoclonal Antibody (J43)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Specificity: This antibody is specific for murine PD-1.

Target Information

Cell-mediated immune responses are initiated by T lymphocytes that are stimulated by peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is self-limited as activated T cells express receptors such as PD-1 (PDCD-1) that mediate inhibitory signals from APCs.
PD-1 binds to two related ligands, PDL-1 and PDL-2. Upon ligand binding, PD-1 signaling inhibits immune activation in the absence of danger signals (e.g., LPS or bacterial molecules).
PD1-deficient mice exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at a higher molecular weight in SDS-PAGE.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.