Thermo Fisher Scientific FceR1 alpha Chimeric Recombinant Rabbit Monoclonal Antibody (IE7)

Applications

Product Specifications

Product Specific Information

Specificity: This antibody binds to human Fc epsilon receptor, but does not compete with IgE binding.

Target Information

FceR1 (Fc epsilonR1 alpha) is a subunit of the high affinity receptor of IgE. Fc epsilonR1 alpha is part of a tetrameric complex consisting of one alpha, one beta, and two additional subunits required for signal transduction. The Fc epsilonR1 complex plays a key role in triggering allergic responses. When allergen-bound IgE molecules bring together two or more high-affinity IgE receptors, mediators such as histamine are released, leading to allergic symptoms. This receptor couples allergens and mast cells to initiate inflammatory responses characteristic of disorders such as hay fever and asthma. The release of histamine and proteases leads to the synthesis of prostaglandins and leukotrienes, potent effectors of hypersensitivity responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.