Thermo Fisher Scientific PTEN Polyclonal Antibody

Applications and Tested Dilution

Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Based on 100% sequence identity, this antibody is predicted to react with Dog.

Product Specifications

Target Information

PTEN was identified as a tumor suppressor frequently mutated in various cancers. The PTEN gene encodes a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase containing a tensin-like domain and a catalytic domain similar to dual specificity protein tyrosine phosphatases. Unlike most tyrosine phosphatases, PTEN preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular phosphatidylinositol-3,4,5-trisphosphate levels and functions as a tumor suppressor by inhibiting the AKT/PKB signaling pathway. PTEN also modulates the AKT-mTOR pathway, influencing neuronal integration, dendritic development, and synapse formation during adult neurogenesis. Additionally, PTEN may act as a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form has higher apoptotic potential, while the cytoplasmic nonubiquitinated form shows reduced tumor suppressive activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.