Thermo Fisher Scientific PTEN Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections
• Based on 100% sequence identity, this antibody is predicted to react with Dog

Target Information

PTEN was identified as a tumor suppressor frequently mutated in various cancers. The PTEN gene encodes a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase containing a tensin-like and a catalytic domain similar to dual-specificity protein tyrosine phosphatases. Unlike most phosphatases, PTEN preferentially dephosphorylates phosphoinositide substrates and negatively regulates intracellular PIP3 levels, thereby inhibiting the AKT/PKB signaling pathway.
PTEN is a key modulator in the AKT-mTOR signaling pathway, influencing neuronal integration, positioning, dendritic development, and synapse formation during adult neurogenesis. It may also act as a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form exhibits greater apoptotic potential, while the cytoplasmic nonubiquitinated form shows reduced tumor suppressive ability.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.