Thermo Fisher Scientific TRIB1 Monoclonal Antibody (OTI8C8), TrueMAB
인간 TRIB1 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB 및 IHC(P) 검증 완료. 동결건조 형태로 제공되며, 재구성 후 약 1 mg/mL 농도 유지. 연구용으로 단백질 결합 및 신호전달 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8C8 |
| Immunogen | Full length human recombinant protein of human TRIB1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
TRIB1, also known as gprotein coupled receptor induced, skip1, gig2, c8fwATP, is involved in protein binding, protein kinase inhibitor activity, and protein serine/threonine kinase activities.
Overexpression of TRIB1 in HeLa cells represses IL8 promoter activity by inhibiting AP1. It also inhibits Ras-driven and MEKK1-mediated AP1 activation, while enhancing ERK activation.
Coimmunoprecipitation and yeast two-hybrid assays show that MEK1 interacts with TRIB1 and TRIB3, and MKK4 interacts specifically with TRIB1. Cotransfection of MKK4 stabilizes TRIB1 through TRIB-MAPKK interaction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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