Thermo Fisher Scientific BAG4 Polyclonal Antibody
BAG4 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. 합성 펩타이드 면역원 기반, Affinity chromatography로 정제. PBS/glycerol buffer, -20°C 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BAG4 (Accession O95429), corresponding to amino acid residues N329–S379 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854480 |
Product Specific Information
Antibody detects endogenous levels of total BAG4.
Target Information
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with various apoptosis and growth-related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors, and members of the Hsp70 family. This protein contains a BAG domain near the C-terminus, which can bind and inhibit the chaperone activity of Hsc70/Hsp70. It associates with the death domain of TNF-R1 and DR3, thereby negatively regulating downstream cell death signaling. Its regulatory role in apoptosis has been demonstrated in epithelial cells that undergo apoptosis upon loss of integrin-mediated matrix contacts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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