Thermo Fisher Scientific NRL Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total NRL.

Target Information

Nrl (neural retina leucine zipper) is a member of the Maf family of transcription factors, which characteristically contain a highly conserved basic leucine zipper (bZIP)-DNA binding motif. Both Nrl and c-Maf preferentially bind to T-MARE sites and are implicated in various developmental and physiologic roles. The Maf-Nrl subfamily regulates expression of cell type-specific genes in tissues of the hematopoietic system, cerebellum, and developing hindbrain. Maf and Nrl proteins bind an extended AP-1-like sequence and can form heterodimers with Fos and Jun transcription factors. In retinal and photoreceptor cells, Nrl promotes rhodopsin expression through binding to the Nrl response element in the rhodopsin promoter. Nrl is expressed throughout the developing central and peripheral nervous system during neuronal differentiation, and its expression becomes restricted to neocortex, brainstem, and retinal neurons in adulthood.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.