Thermo Fisher Scientific N4BP1 Polyclonal Antibody
인간 N4BP1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 -20°C에서 보관. 연구용 전용 제품.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- References: [참고 문헌 링크]
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
- References: [참고 문헌 링크]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human N4BP1 (Accession O75113), corresponding to amino acid residues E382–A432 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851135 |
Product Specific Information
Antibody detects endogenous levels of total N4BP1.
Target Information
Nedd4-binding partner-1 (N4BP1) is a developmentally expressed protein interactor and monoubiquitylation substrate of Nedd4, a HECT domain-containing ubiquitin ligase that mediates ubiquitylation and proteasome degradation of target proteins and may have a fundamental role in embryonic processes.
N4BP1 can undergo Nedd4-mediated polyubiquitylation and proteosomal degradation. It also functions as a negative regulator of AIF4 (ITCH or Atrophin-1), an E3-ubiquitin ligase, by interacting with the second WW domain of AIF4 and impairing ubiquitination of substrates.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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