Thermo Fisher Scientific NPDC1 Polyclonal Antibody
Thermo Fisher Scientific의 NPDC1 폴리클로날 항체로, 인간, 마우스, 랫트 시료에 반응합니다. Western blot, IHC, ICC/IF에 적합하며, 고순도의 Affinity chromatography로 정제되었습니다. 액상 형태로 제공되며 -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NPDC1 (Accession Q9NQX5), corresponding to amino acid residues I188–G238 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851138 |
Product Specific Information
Antibody detects endogenous levels of total NPDC1.
Target Information
The discovery of NPDC-1 (neuronal proliferation, differentiation and control protein 1) was the result of a study of genes that were preferentially expressed in immortalized neural precursor cell lines at the onset of contact inhibition of proliferation and subsequent differentiation. Transfection of transformed cells with NPDC-1 led to increased doubling times and suppression of many characteristics of transformation. NPDC-1 is differentially expressed in brain and lung and interacts directly with the transcription factor E2F-1, D-type cyclins, and cdk2. It acts as a modulator of transcriptional events mediated by retinoic acid, and its protein level and activity are regulated by phosphorylation-mediated proteasomal degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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