Thermo Fisher Scientific ITGB1 Polyclonal Antibody

Thermo Fisher Scientific ITGB1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Percent identity with other species by BLAST analysis:
  Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset (100%); Dog, Bat, Panda, Horse (94%); Sheep, Bovine, Cat, Elephant, Pig (88%)
• For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer.
  After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Target Information

ITGB1 (Integrin Subunit Beta 1, beta1 integrin subunit, GPIIa, CD29) is a 110 kDa cell surface glycoprotein widely expressed by various cells including all leukocytes. ITGB1 forms non-covalently linked heterodimers with at least six different alpha chains (α1–α6, CDa–f), determining the binding properties of beta1 (VLA) integrins.

ITGB1 functions as a cell adhesion molecule on platelets and as a component of protein complexes binding to extracellular matrix proteins. Decreased expression correlates with multidrug resistance in tumor cells. It is up-regulated in leukocytes during migration and plays a critical role in immune cell trafficking.

Additionally, ITGB1 regulates tissue damage and inflammatory responses such as those in inflammatory bowel disease. Through ITGB1-dependent mechanisms, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1β.

More than eight beta subunits with numerous splice variants exist in mammals. Two major forms—beta1A and beta1D—differ by 13 amino acids and exhibit mutually exclusive tissue distribution: beta1A in all tissues except cardiac and skeletal muscle, which express beta1D.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.