Thermo Fisher Scientific GABBR1 Polyclonal Antibody
GABBR1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 다양한 종에서 반응하며, IHC(P) 등 연구용으로 사용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 안정성 제공. 연구용 전용 제품.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 9–18 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Hamster, Human, Mouse, Non-human primate, Pig, Rabbit, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 15 amino acid peptide from N-terminal extracellular domain of human GABBR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550946 |
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Monkey, Mouse, Rat, Hamster, Elephant, Panda, Bovine, Rabbit, Pig, Opossum (100%).
Target Information
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulate phospholipase A2, activate potassium channels, inactivate voltage-dependent calcium channels, and modulate inositol phospholipids hydrolysis.
Plays a critical role in fine-tuning inhibitory synaptic transmission.
Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating inwardly rectifying potassium (Kir) conductance.
Involved in synaptic inhibition, hippocampal long-term potentiation, slow wave sleep, muscle relaxation, and antinociception.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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