Thermo Fisher Scientific FZD8 Polyclonal Antibody
FZD8 단백질을 표적으로 하는 Thermo Fisher Scientific의 폴리클로날 항체. 다양한 종(인간, 마우스, 말 등)에 반응하며 IHC(P) 실험에 적합. 항원 친화 크로마토그래피로 정제된 액상 제품으로, 암 관련 연구에 활용 가능.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 7–17 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Horse, Human, Mouse, Non-human primate, Rat, Xenopus |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 12 amino acid peptide from N-terminal extracellular domain of human FZD8 / Frizzled 8 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2550943 |
Product Specific Information
Percent identity with other species by BLAST analysis: Human, Monkey, Marmoset, Mouse, Rat, Panda, Bovine, Horse, Opossum, Xenopus (100%).
Target Information
Members of the Frizzled family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most Frizzled receptors are coupled to the beta-catenin canonical signaling pathway.
Frizzled 8 is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. Its expression has been reported in brain, heart, kidney, pancreas, and skeletal muscle. ESTs have been isolated from embryo, eye, head/neck, heart, kidney, liver/spleen, pancreas, prostate, and testis libraries, as well as many tumor libraries.
The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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