Thermo Fisher Scientific LRRC25 Monoclonal Antibody (OTI1B3), TrueMAB
인간 LRRC25 단백질을 인식하는 Mouse IgG2b 단일클론 항체로, Western blot과 Flow cytometry에 적합합니다. 고순도의 액상 형태로 제공되며, PBS/BSA/glycerol 완충액에 보관됩니다. RLR-매개 인터페론 신호 억제 연구에 활용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B3 |
| Immunogen | Full length human recombinant protein of human LRRC25 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation.
Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy (PubMed:29288164).
Also plays a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting degradation of p65/RELA. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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