Thermo Fisher Scientific LRRC25 Monoclonal Antibody (OTI1D4), TrueMAB
LRRC25 단백질을 인식하는 Mouse IgG1 단일클론 항체로, WB, IHC, ICC/IF, Flow Cytometry에 사용 가능. 고순도 Affinity chromatography 정제, PBS/BSA/glycerol 버퍼에 보관. RLR 및 NF-κB 신호 억제 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D4 |
| Immunogen | Full length human recombinant protein of human LRRC25 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.27 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
LRRC25 plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. It interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1, mediating DDX58 degradation via selective autophagy (PubMed:29288164). LRRC25 also contributes to inhibition of NF-κB signaling and inflammatory responses by promoting degradation of p65/RELA. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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