Thermo Fisher Scientific PSMD11 Polyclonal Antibody
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PSMD11 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot에 최적화되어 있습니다. Human, Mouse, Rat 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. -20°C에서 보관하며 연구용으로 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region derived from internal residues of human proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2636019 |
Product Specific Information
This antibody detects endogenous levels of total PSMD11 protein.
Target Information
The 26S proteasome (PSMD11) is a multicatalytic proteinase complex with a highly ordered structure composed of two complexes: a 20S core and a 19S regulator.
- The 20S core consists of four rings of 28 non-identical subunits (two rings of seven alpha subunits and two rings of seven beta subunits).
- The 19S regulator includes a base (with six ATPase subunits and two non-ATPase subunits) and a lid (up to ten non-ATPase subunits).
Proteasomes are widely distributed in eukaryotic cells and cleave peptides in an ATP/ubiquitin-dependent process within a non-lysosomal pathway.
A key function of the immunoproteasome is the processing of class I MHC peptides. PSMD11 is a non-ATPase subunit of the 19S regulator.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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