Thermo Fisher Scientific IKK epsilon Recombinant Rabbit Monoclonal Antibody (23GB2720)

Thermo Fisher Scientific IKK epsilon Recombinant Rabbit Monoclonal Antibody (23GB2720)

Applications and Tested Dilution

Product Specifications

Target Information

IKBKE is an activator of nuclear factor-kappa-B. Overexpression of IKBKE has been observed in breast cancer cells, and suppression of IKBKE induces cell death. NF-kappa-B is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. It mediates the expression of various genes in response to extracellular stimuli. NF-kappa-B is associated with Ikappa-B proteins in the cytoplasm, which inhibit NF-kappa-B activity. Ikappa-B is phosphorylated by the Ikappa-B kinase (IKK) complex containing IKK-α, IKK-β, and IKK-γ. A novel molecule in the IKK complex, designated IKK-iota/IKK-i, was recently identified. IKK epsilon is required for activation of NF-kappa-B by PMA and T cell receptors but not by TNF-α and IL-1. IKK-iota/IKK-i expression is inducible by TNF-α, IL-1, and LPS.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.