Thermo Fisher Scientific ASGR1 Polyclonal Antibody
ASGR1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. 인간 ASGR1 N말단 합성 펩타이드를 면역원으로 제작되었습니다. 단백질 A로 정제되었으며, PBS와 2% sucrose buffer에 보관됩니다. -20°C에서 보관하고 동결/해동을 피해야 합니다.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 0.2–1.0 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal region of human ASGR1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2688998 |
Product Specific Information
This target displays homology in the following species:
Cow: 85%; Guinea Pig: 92%; Horse: 86%; Human: 100%; Mouse: 91%; Pig: 93%; Rat: 92%; Yeast: 75%
Target Information
The asialoglycoprotein receptor (ASGPR) is a transmembrane glycoprotein (42 kDa) that mediates binding, internalization, and degradation of extracellular glycoproteins with exposed terminal galactose residues.
It is expressed on hepatocyte surfaces in a polar manner — present on sinusoidal and lateral plasma membranes but absent from the bile canalicular membrane.
Mammalian hepatic ASGPR mediates endocytosis and degradation of serum proteins lacking terminal sialic residues.
The rat ASGPR consists of three polypeptide subunits: RHL-1, RHL-2, and RHL-3.
The monoclonal antibody 8D7 recognizes a subunit-specific epitope of RHL-1 and is cross-reactive with human ASGPR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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