Thermo Fisher Scientific Tankyrase Polyclonal Antibody
Tankyrase 단백질을 인식하는 Rabbit Polyclonal 항체로 Western Blot, IHC 등 다양한 응용에 적합. Wnt 신호전달, 텔로미어 길이 조절, 소포 수송 관련 연구에 활용 가능. 고순도 친화 크로마토그래피 정제, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1.0 µg/mL |
| Immunohistochemistry (IHC) | 1:600 |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-Dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human Tankyrase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2689494 |
Product Specific Information
This target displays homology in the following species:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Target Information
Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length, and vesicle trafficking (PubMed:10988299, PubMed:11739745, PubMed:16076287, PubMed:19759537, PubMed:21478859, PubMed:22864114, PubMed:23622245, PubMed:25043379).
Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, key components of the beta-catenin destruction complex. Poly-ADP-ribosylated target proteins are recognized by RNF146, leading to ubiquitination and degradation (PubMed:19759537, PubMed:21478859).
Also mediates PARsylation of BLZF1 and CASC3, followed by RNF146 recruitment and ubiquitination (PubMed:21478859).
Mediates PARsylation of TERF1, contributing to telomere length regulation (PubMed:11739745).
Involved in centrosome maturation during prometaphase via PARsylation of HEPACAM2/MIKI (PubMed:22864114).
May regulate vesicle trafficking and modulate SLC2A4/GLUT4-vesicle distribution (PubMed:10988299).
May participate in spindle pole assembly through PARsylation of NUMA1 (PubMed:16076287).
Stimulates 26S proteasome activity (PubMed:23622245).
[Source: UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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