Thermo Fisher Scientific CD66 Monoclonal Antibody (CD66a-B1.1), PE, eBioscience

Thermo Fisher Scientific CD66 Monoclonal Antibody (CD66a-B1.1), PE, eBioscience

Applications

• Flow Cytometry (Flow)

Tested Dilution: 5 µL (0.25 µg)/test
Publications: View 1 publication

Product Specifications

Additional Formats

• Alexa Fluor 488
• APC
• Super Bright 436
• Super Bright 702
• Request custom conjugation

Product Specific Information

The CD66a-B1.1 monoclonal antibody reacts with human CD66a, c, d, and e (CEACAM1, CEACAM6, CEACAM3, and CEA). CD66 is expressed on endothelial and epithelial cells, neutrophils, and monocytes, and can be induced on T cells, B cells, and CD16-negative NK cells. It exists as multiple splice variants containing ITIM motifs that mediate inhibitory functions on T and NK cells. CD66 is involved in cell adhesion, growth, neutrophil activation, and signaling, and interacts homo- and heterotypically among variants.

Applications Reported: Suitable for flow cytometric analysis.
Applications Tested: Pre-diluted and tested on normal human peripheral blood cells at 5 µL (0.25 µg) per test.
A test corresponds to staining a cell sample (10⁵–10⁸ cells) in 100 µL final volume.

Excitation: 488–561 nm
Emission: 578 nm
Laser Compatibility: Blue, Green, Yellow-Green Lasers

Target Information

CD66 molecules are 180–200 kDa glycoproteins of the carcinoembryonic antigen family. They are present on blood granulocytes and some tissue macrophages but absent from other hematopoietic cells. Expression increases upon granulocyte activation.

• CD66a (CEACAM1) and CD66d (CEACAM3), as well as CEACAM2 and 4, are transmembrane proteins.
• CD66c (CEACAM6) and CD66e (CEACAM5), as well as CEACAM7 and 8, are GPI-anchored membrane proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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