Thermo Fisher Scientific SOCS5 Polyclonal Antibody
Thermo Fisher Scientific SOCS5 Polyclonal Antibody는 인간 SOCS5 단백질을 인식하는 염소 유래 IgG 항체로, WB 및 ICC/IF에 최적화되어 있습니다. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼에 동결건조 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA548060
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: 5–15 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | E. coli-derived recombinant human SOCS-5 (Met1–Lys536) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2610084 |
Product Specific Information
- In direct ELISAs, less than 1% cross-reactivity with recombinant human SOCS-1, -2, -3, -6, and -7 is observed.
- Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling).
Eight members of the SOCS family have been identified: SOCS-1, 2, 3, 4, 5, 6, 7, and CIS.
Structurally, SOCS proteins consist of:
- An N-terminal region of variable length and composition
- A central SH2 domain
- A C-terminal SOCS box motif
SOCS proteins form a classical negative feedback loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of SOCS genes occurs rapidly in response to cytokines, and each member inhibits signaling through distinct mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(PA5-48060_SOCS5_O75159-1_Goat.svg 및 PA5-48060_SOCS5_O75159-1_Goat_PDP.jpeg 이미지 참조)
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