Thermo Fisher Scientific NALP12 Polyclonal Antibody
인간 NALP12 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, IP 등 다양한 응용에 적합. 염증 반응 조절 관련 연구에 활용 가능. -20°C에서 보관하며, 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:1,000–1:5,000 |
| Immunohistochemistry (Frozen) (IHC-F) | Assay-dependent |
| Immunoprecipitation (IP) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to amino acids 190–208 of human NALP12/PYPAF7/Monarch-1 (NP_653288). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2718765 |
Target Information
NALP proteins are cytoplasmic proteins forming a subfamily within the larger CATERPILLER family and play crucial roles in cell proliferation and reproduction. NALP12 (Monarch-1) contains a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD), a NACHT domain, and a NACHT-associated domain. It acts as an attenuating factor of inflammation by suppressing NF-kappa-B activation through TLR-signaling molecules such as MyD88, IRAK-1, TRAF6, and RIPK1 in activated monocytes. Mutations in NALP12 are associated with hereditary periodic fever syndromes.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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