Thermo Fisher Scientific FBXL20 Polyclonal Antibody
FBXL20 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot 및 IHC에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 1 mg/mL 농도, 2–8°C 보관 권장.
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Thermo Fisher Scientific FBXL20 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–1 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide near the carboxy terminus of the human SCRAPPER |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11156600 |
Product Specific Information
- Suggested positive control: A-20 cell lysate
- PA5-20485 can be used with blocking peptide PEP-0605
Target Information
Members of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases.
Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS, and is abundant at presynaptic membranes.
Scrapper has orthologs in C. elegans, D. melanogaster, and mammals, suggesting that it may function as an important membrane-localized E3 ligase in various species.
Scrapper acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to regulate synaptic transmission, identifying protein degradation as a mechanism for maintaining synaptic communication balance.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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