Thermo Fisher Scientific FGF4 Polyclonal Antibody
FGF4 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 Immunocytochemistry에 적합합니다. Human과 Mouse에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포 성장 및 분화 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–1 µg/mL |
| Immunocytochemistry (ICC/IF) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide near the carboxy terminus of the human FGF4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152903 |
Product Specific Information
- A suggested positive control is NIH-3T3 cell lysate.
- PA5-20483 can be used with blocking peptide PEP-0603.
Target Information
Fibroblast growth factor 4 (FGF4) is a member of the fibroblast growth factor (FGF) family that possesses broad mitogenic and cell survival activities. It plays key roles in the growth and survival of stem cells during embryogenesis, tissue regeneration, and carcinogenesis.
FGF4 exhibits strong oncogenic transforming activity and acts as a potent angiogenic factor, expressed in several highly vascularized tumors as well as in adult mouse testis, intestine, and brain.
Mouse studies suggest a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. Additionally, FGF4 regulates neural progenitor cell proliferation and neuronal differentiation.
Recent research indicates a growth-promoting role for FGF4 in human embryonic stem cells and a feedback inhibition mechanism via a novel FGF4 splice isoform that may promote differentiation in later developmental stages.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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