Thermo Fisher Scientific Kv2.2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human Kv2.2 (KCNB2). Validated for WB, IHC, ICC/IF, and ELISA. Recognizes voltage-gated potassium channel involved in neuronal excitability. Supplied as liquid, 1 mg/mL, Protein A purified, for research use only.
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Thermo Fisher Scientific Kv2.2 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide derived from human Kv2.2 (amino acids 21–120) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA and 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Kcnb2 (Kv2.2) encodes a voltage-gated potassium (K⁺) channel that plays a key role in neuronal membrane excitability. Differences in K⁺ channel expression and density contribute to variations in action potential waveforms and firing patterns among neuronal cell types. Delayed rectifier-type IK channels (Kv1.5, Kv2.1, Kv2.2) are expressed in neuronal somata and dendrites, as well as in non-neuronal cells such as pancreatic islets, alveolar cells, and cardiac myocytes. Kv2.1 and Kcnb2 form distinct K⁺ channel populations, primarily responsible for IK in superior cervical ganglion cells. Functionally, Kcnb2 mediates voltage-dependent potassium ion permeability, opening or closing in response to membrane potential changes. Diseases associated with KCNB2 include Brugada Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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