Thermo Fisher Scientific RHBDD3 Polyclonal Antibody
RHBDD3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합. Protein A로 정제된 고순도 항체로, -20°C에서 안정적 보관 가능. 인간, 생쥐, 랫트에 반응.
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Thermo Fisher Scientific RHBDD3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human RHBDD3 (101–200 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Rhomboid family of proteins comprises widely conserved polytopic membrane serine proteases involved in growth and development. RHBDD3 was first identified as a novel pituitary tumor apoptosis gene (PTAG) with reduced expression in certain pituitary adenomas. Overexpression of RHBDD3 in AtT20 cells increases apoptotic activity and caspase activation in response to bromocriptine, indicating potential therapeutic relevance through reactivation of RHBDD3 in tumors. Reduced RHBDD3 expression has also been observed in primary colorectal tumors, suggesting its loss contributes to impaired apoptosis and malignant transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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