Thermo Fisher Scientific Alpha 1 acid glycoprotein 2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

AGP (α1-acid Glycoprotein) is an acute-phase plasma protein synthesized by the liver. It regulates interactions between blood and endothelial cells and, along with haptoglobin and C-reactive protein, mediates cell extravasation during infection and inflammation.
Expression of AGP is induced by acute-phase stimulatory agents such as bacterial lipopolysaccharides. It has high-affinity, low-capacity binding for basic drugs at physiological pH.
In human plasma, AGP levels range from 0.5–1.4 mg/mL, increasing during acute inflammation. Thus, AGP levels can serve as indicators for inflammatory conditions.
Multiple AGP genes exist, including AGP-1, AGP-2, AGP-3, and AGP-8. AGP-1 and AGP-2 contain five and six potential N-glycosylation sites, respectively.
Abnormal expression of the AGP-1 gene is linked to sarcoidosis and other immunogenetic diseases, while mutations in the AGP-2 gene are associated with various carcinomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.