Thermo Fisher Scientific CMKLR1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  NRLAKTKKPF KIIVTIIITF FLCWCPYHTL NLLELHHTAM PGSVFSLGLP LATALAIANS CMNPILYVFM GQDFKKFKVA LFSRLVNALS EDTGHSSYPS H
• Positive Samples: LO2, Mouse brain
• Cellular Location: Cell membrane, Multi-pass membrane protein

Target Information

Chemokine-like receptor 1 (CMKLR1) acts as a receptor for the chemoattractant adipokine chemerin (RARRES2) and the omega-3 fatty acid-derived molecule resolvin E1.
Interaction with RARRES2 triggers intracellular signaling pathways including SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK, and PI3K, resulting in modulation of immune response, adipogenesis, and angiogenesis.
Resolvin E1 reduces cytokine production in macrophages by inhibiting MAPK1/3 (ERK1/2) and NF-κB activation.
CMKLR1 also regulates adipocyte metabolism and serves as a co-receptor for several SIV and HIV-1 strains.

주의사항

⚠ WARNING:
This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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