Thermo Fisher Scientific CD368 (Clec6) Monoclonal Antibody (9B9), eFluor 660, eBioscience

Thermo Fisher Scientific CD368 (Clec6) Monoclonal Antibody (9B9), eFluor 660, eBioscience

Applications

• Flow Cytometry (Flow)

Tested Dilution: 5 µL (0.5 µg)/test

Product Specifications

Product Specific Information

This 9B9 monoclonal antibody reacts with human CD368, also known as Clec6, ClecsF8, or Clec4D. In peripheral blood, CD368 is highly expressed on granulocytes and CD14⁺CD16⁻ monocytes, with low expression in some dendritic cells.
CD368 is a C-type lectin receptor involved in endocytosis, phagocytosis, and proinflammatory cytokine production in cooperation with Toll-like receptors. It also mediates cellular activation via Syk kinase signaling.

Applications Reported: Suitable for flow cytometric analysis.
Due to the endocytic nature of Clec6, fixation prior to staining is recommended for optimal signal.

Applications Tested: Pre-titrated and validated for flow cytometric analysis of normal human peripheral blood cells.
Use at 5 µL (0.5 µg) per test (defined as antibody amount for 100 µL staining volume).
Cell number may vary between 10⁵–10⁸ cells/test.

Fluorophore Information:
eFluor® 660 replaces Alexa Fluor® 647, emits at 659 nm, and is excited with a red laser (633 nm).
Ensure instrument compatibility for detection.

Excitation/Emission: 633–647 nm / 668 nm
Laser: Red Laser
Filtration: 0.2 µm post-manufacturing filtered

Target Information

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily.
Members of this family share a common protein fold and have diverse functions, including:

• Cell adhesion
• Cell-cell signaling
• Glycoprotein turnover
• Inflammation and immune response

This gene is closely linked to other CTL/CTLD family members on chromosome 12p13 in the natural killer gene complex region.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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