Thermo Fisher Scientific TAFA5 Monoclonal Antibody (463102)

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

8-25 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rat / IgG1

Class

Monoclonal

Type

Antibody

Clone

463102

Immunogen

E. coli-derived recombinant human TAFA5/FAM19A5 Gln26-Ser125 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TAFA5,uniProtId:Q7Z5A7-1,ncbiNodeId:9606,antigenRange:26-125,antigenLength:132,antigenImageFileName:MA5-24183_TAFA5_Q7Z5A7-1_Rat.svg,antigenImageFileNamePDP:MA5-24183_TAFA5_Q7Z5A7-1_Rat_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2607053

Product Specific Information

In direct ELISAs and Western blots, no cross-reactivity with recombinant human TAFA2, 3, or 4 is observed.

Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2. Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway. Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes. Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2. Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling . Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.