Thermo Fisher Scientific mGluR5 Monoclonal Antibody (464818)

Applications

Western Blot (WB)

• Tested Dilution: 1 µg/mL

Flow Cytometry (Flow)

• Tested Dilution: 2.5 µg per million cells

Product Specifications

Product Specific Information

• In direct ELISAs and Western blots, no cross-reactivity with recombinant human mGluR1, R2, R3, R4, R7, or R8 is observed.
• Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

GRK1 is a member of the guanine nucleotide protein-coupled (G protein) receptor kinase subfamily of Serine/Threonine kinase family. GRK1 phosphorylates rhodopsin and initiates its deactivation. G protein mediated phosphorylation promotes the binding of arrestin, which removes the receptor from the G-protein and terminates the receptor signal chain. GRK1 is farnesylated to promote membrane association. Studies have shown that GRK1 has been shown to be inhibited by recoverin, a Calcium binding protein. Diseases associated with GRK1 protein dysfunction include Oguchi Disease-2 and Hereditary Night Blindness.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: MA5-24185_mGluR5_P41594-1_House_mouse.svg, MA5-24185_mGluR5_P41594-1_House_mouse_PDP.jpeg)