Thermo Fisher Scientific CD38 (ADP Ribosyl Cyclase I) Monoclonal Antibody (rCD38/6982)
CD38 단백질을 인식하는 Mouse monoclonal antibody로, 인간 시료에 반응합니다. IHC(P) 및 IHC(PFA) 적용 가능하며, Protein A/G로 정제된 액상 형태입니다. 세포 표면 CD38 검출 및 림프구 활성화 연구에 적합합니다.
- 카탈로그번호
- 952-MSM12-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD38 (ADP Ribosyl Cyclase I) Monoclonal Antibody (rCD38/6982)
Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 2 µg/mL
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rCD38/6982 |
| Immunogen | Recombinant fragment (around aa1–300) of human CD38 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD38 (NAD⁺ glycohydrolase) is a type II transmembrane glycoprotein that induces activation, proliferation, and differentiation of mature lymphocytes and mediates apoptosis of myeloid and lymphoid progenitor cells.
It functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and possibly NAD⁺ glycohydrolase or as a cell surface receptor.
Antibodies to CD38 are useful in:
- Subtyping of lymphomas and leukemias
- Detection of plasma cells (e.g., identification of myelomas)
- Marking activated B and T cells
CD38 is involved in cell adhesion, signal transduction, and calcium signaling, and is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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