Thermo Fisher Scientific Phospho-PAK3 (Ser186) Polyclonal Antibody
PAK3 단백질의 Ser186 인산화 형태를 특이적으로 인식하는 폴리클로날 항체. Western blot에 적합하며 사람, 생쥐, 랫드 시료에 반응. PBS 기반 완충액에 50% 글리세롤 포함, -20°C에서 보관. 연구용으로만 사용 가능.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PAK3 (Accession O75914), corresponding to amino acid residues around phosphorylated Ser186 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816861 |
Product Specific Information
This antibody detects endogenous levels of PAK3 only when phosphorylated at Ser186.
Target Information
PAK proteins are critical effectors linking Rho GTPases to cytoskeleton reorganization and nuclear signaling.
They are serine/threonine p21-activating kinases that serve as targets for small GTP-binding proteins Cdc42 and RAC, and are involved in various biological processes.
Alpha, beta, and gamma PAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting intrinsic GTPase activity and leading to autophosphorylation.
There are eight autophosphorylation sites on gammaPAK, including Ser19, Ser141, and Thr402, with phosphorylation of Ser141 and Thr402 correlated with activation.
Once phosphorylated, the PAK isoforms reduce affinity for Rac/Cdc42 and dissociate to interact with downstream substrates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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