Thermo Fisher Scientific Phospho-Nephrin (Tyr1176) Polyclonal Antibody
Nephrin의 Tyr1176 인산화 형태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot에 최적화되어 있으며, 인간 및 마우스 시료에 반응. 1 mg/mL 농도의 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용 가능.
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- PA5105709
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- pk
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Thermo Fisher Scientific Phospho-Nephrin (Tyr1176) Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:2,000
Species Reactivity
- Human
- Mouse
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NPHS1 (Accession O60500), corresponding to amino acid residues around phosphorylated Tyr1176 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817137 |
Product Specific Information
Phospho-Nephrin (Tyr1176) Antibody detects endogenous levels of Nephrin only when phosphorylated at Tyr1176.
Target Information
Primary steroid-resistant nephrotic syndrome (SRNS) is characterized by childhood onset of proteinuria and progression to end-stage renal disease. Kidney podocytes and their slit diaphragms form the final barrier to urinary protein loss.
Congenital nephrotic syndrome (CNS) is caused by mutations in NPHS1 (nephrin) or NPHS2. Nephrin is a cell adhesion molecule and a key component of the slit diaphragm, playing a crucial role in maintaining the glomerular filtration barrier.
Mutations in the Nephrin gene can lead to congenital nephrosis. Podocin, Nephrin, and alpha Actinin 4 are major podocyte proteins associated with proteinuria. Nephrin’s anti-apoptotic activity in podocytes is linked to VEGF signaling and may help anchor the slit diaphragm to the actin cytoskeleton.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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