Thermo Fisher Scientific CD38 Monoclonal Antibody (90), PE, eBioscience

Thermo Fisher Scientific CD38 Monoclonal Antibody (90), PE, eBioscience™

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 0.06 µg/test
  View 27 publications

Product Specifications

Available Formats

• Unconjugated
• Alexa Fluor 700
• APC
• APC-eFluor 780
• Biotin
• Brilliant UV 395
• Brilliant Violet 480
• Brilliant Violet 605
• eFluor 450
• FITC
• Functional Grade
• PE-Cyanine5
• PE-Cyanine7
• PE-eFluor 610
• PerCP-eFluor 710
• Request custom conjugation

Product Specific Information

The 90 monoclonal antibody reacts with the mouse CD38 molecule, a ~42 kDa type II transmembrane protein.
CD38 expression increases on B cells through differentiation stages and is down-regulated on germinal center B cells and mature plasma cells. It is also expressed on subsets of thymocytes, mature T cells, and NK cells.

Crosslinking of CD38 on mature B cells induces proliferation, enhanced by co-signals such as IL-4 and LPS. CD38 acts as a counter-receptor for CD31 and functions as an ectoenzyme with cyclase and hydrolase activity, playing roles in lymphocyte activation and differentiation.

Applications Reported: Flow cytometric analysis.
Applications Tested: Mouse splenocytes; ≤0.06 µg/test (100 µL final volume).
Cell number range: 10⁵–10⁸ cells/test. Titrate for optimal performance.

Excitation: 488–561 nm
Emission: 578 nm
Laser: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered.

Target Information

CD38 (NAD⁺ glycohydrolase) is a type II transmembrane glycoprotein involved in activation, proliferation, and differentiation of lymphocytes and apoptosis of progenitor cells.
Functions as a multi-catalytic ectoenzyme (ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, NAD⁺ glycohydrolase) or as a cell surface receptor.

Antibodies to CD38 are useful for:

• Subtyping lymphomas and leukemias
• Plasma cell detection (e.g., myelomas)
• Marker for activated B and T cells

CD38 participates in cell adhesion, signal transduction, and calcium signaling, and is expressed in pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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