Thermo Fisher Scientific CD122 Polyclonal Antibody
Rabbit polyclonal antibody against human CD122 (IL2RB). Validated for Western blot at 0.1–0.5 µg/mL. Supplied lyophilized, reconstitutable to 500 µg/mL. Purified by antigen affinity chromatography. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to a sequence in the middle region of human IL2RB (117–135aa RVMAIQDFKPFENLRLMAP) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5 mg BSA |
| Contains | 0.05 mg sodium azide, 0.05 mg thimerosal |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2746610 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
CD122 (Interleukin 2 receptor beta chain, IL2RB) is involved in T cell-mediated immune responses and is primarily expressed in the hematopoietic system. It exists in three forms:
- Low affinity form: Monomer (alpha subunit), not involved in signal transduction
- Intermediate affinity form: Alpha/beta subunit heterodimer
- High affinity form: Alpha/beta/gamma subunit heterotrimer
The intermediate and high affinity forms mediate receptor endocytosis and mitogenic signal transduction. CD122 encodes the beta subunit, a type I membrane protein. Dysfunctions are associated with oligoarticular juvenile idiopathic arthritis and rheumatoid factor-negative juvenile idiopathic arthritis.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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