Thermo Fisher Scientific Nkx2.1 Monoclonal Antibody (8G7G3/1)

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

-

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

-

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Not Applicable

Host/Isotype

Mouse

Class

Monoclonal

Type

Antibody

Clone

8G7G3/1

Immunogen

Recombinant full length TTF-1 (Thyroid Transcription Factor 1) protein if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Nkx2.1,uniProtId:P43699-1,ncbiNodeId:9606,antigenRange:1-371,antigenLength:371,antigenImageFileName:18-0221_Nkx2.1_P43699-1_House_mouse.svg,antigenImageFileNamePDP:18-0221_Nkx2.1_P43699-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

purified

Storage buffer

PBS with 1% BSA

Contains

0.1% sodium azide

Storage conditions

2-8°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2925242

Product Specific Information

TTF-1 has been identified as a mediator of thyroid-specific gene transcription, and is involved in the activation of pulmonary-specific genes. TTF-1 is found in primary lung adenocarcinomas and small cell carcinomas. TTF-1 is usually absent in breast and colon carcinomas. TTF-1 monoclonal antibody should be useful in differentiating tumors of lung and non-lung origin. Lung cancer and thyroid gland tissues have been identified positive for TTF-1 monoclonal antibody concentrate.

Target Information

This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.