Thermo Fisher Scientific ABCB1 Monoclonal Antibody (OTI1A3), TrueMAB
인간 ABCB1 단백질을 인식하는 마우스 단일클론 항체로, Western blot에 적합합니다. 무보존제, 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용 가능합니다. 약물 내성 및 P-glycoprotein 연구에 활용됩니다.
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 995–1280 of human ABCB1 produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of about 1 mg/mL.
- For conjugation experiments, perform an additional round of desalting.
Recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882)
Target Information
The membrane-associated protein encoded by the ABCB1 gene belongs to the ATP-binding cassette (ABC) transporter superfamily.
These proteins transport various molecules across cellular membranes and are divided into seven subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White.
The ABCB1 protein is part of the MDR/TAP subfamily, involved in multidrug resistance.
It acts as an ATP-dependent drug efflux pump with broad substrate specificity, contributing to reduced drug accumulation and resistance to anticancer drugs.
Additionally, it functions as a transporter in the blood-brain barrier.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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