Thermo Fisher Scientific BID Monoclonal Antibody (OTI1G1), TrueMAB
인간 BID 단백질을 인식하는 마우스 단클론 항체로 Western blot에 최적화됨. 비결합형 액상 형태로 1 mg/mL 농도, 고순도 친화 크로마토그래피 정제. 세포사멸 연구용으로 사용되며, -20°C에서 보관 권장.
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- TA506765
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- pk
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Applications
- Western Blot (WB)
Tested Dilution
- 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G1 |
| Immunogen | Full length human recombinant protein of human BID produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
BID is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. It is a member of the BCL-2 family of cell death regulators and mediates mitochondrial damage induced by caspase-8 (CASP8). CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria, triggering cytochrome c release. BID exists in an inactive cytosolic form and becomes cleaved and activated by caspase 8 in response to TNF alpha or Fas ligand. The cleaved C-terminal fragment (p15) translocates to mitochondria and induces apoptosis, serving as a molecular link between caspase 8 activation and mitochondrial death machinery.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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