Thermo Fisher Scientific CD44 Monoclonal Antibody (OTI2D9), TrueMAB

Applications and Tested Dilution

• Immunohistochemistry (Paraffin) [IHC (P)]: 1:150

Product Specifications

Target Information

CD44 cell surface antigen is a 100 kDa type I transmembrane glycoprotein widely expressed on human leukocytes, white matter of the brain, and some epithelial cells of the intestine and breast. Several isoforms of CD44 exist, including the predominant CD44H isoform detected in many normal tissues.

CD44 acts as a receptor for hyaluronic acid (HA) and is involved in cell-cell interactions, adhesion, and migration. It also participates in lymphocyte activation, recirculation, and homing. Expression may be up-regulated in certain carcinomas and may be associated with metastatic potential.

CD44 is expressed by hematopoietic and non-hematopoietic cells, epithelial tissues, and filopodia in cultured keratinocytes. Bone marrow myeloid cells and memory T cells express CD44 at high levels, and peripheral B and T cells can upregulate its expression upon stimulation. The CD44 gene undergoes complex alternative splicing, resulting in many functionally distinct isoforms, contributing to its structural and functional diversity.

Diseases associated with CD44 dysfunction include superficial keratitis and lichen sclerosus. CD44 may also be related to tumor metastasis formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.