Thermo Fisher Scientific Phospho-CaMKII alpha/beta/delta (Tyr231) Polyclonal Antibody
CaMKII alpha/beta/delta의 Tyr231 인산화 부위를 인식하는 Rabbit Polyclonal Antibody로, Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 -20°C 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pTyr231 of human CaMKII |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10987028 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The Ca²⁺/calmodulin-dependent protein kinases (CaM kinases) are a structurally related subfamily of serine/threonine kinases that include CaMKI, CaMKII, and CaMKIV.
CaMKII is an ubiquitously expressed serine/threonine protein kinase activated by Ca²⁺ and calmodulin (CaM), and is implicated in regulation of the cell cycle and transcription.
There are four CaMKII isozymes (alpha, beta, gamma, delta), which may or may not be co-expressed in the same tissue type.
CaMKII alpha is autophosphorylated on Thr286 upon binding of the Ca²⁺/CaM complex to its autoinhibitory domain — a process known as Ca²⁺/CaM trapping, thought to be involved in synaptic encoding of information.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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