Thermo Fisher Scientific PABPN1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.
• For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.

Target Information

This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. The protein is required for progressive and efficient polymerization of poly(A) tails at the 3′ ends of eukaryotic transcripts and controls the size of the poly(A) tail to about 250 nt.
At steady-state, this protein is localized in the nucleus, whereas a different poly(A) binding protein is localized in the cytoplasm.
This gene contains a GCG trinucleotide repeat at the 5′ end of the coding region, and expansion of this repeat from the normal 6 copies to 8–13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD).
Related pseudogenes have been identified on chromosomes 19 and X. Read-through transcription also exists between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.