Thermo Fisher Scientific PABPN1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Application Note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
• Based on 100% sequence identity, this antibody is predicted to react with Bovine.

Target Information

This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. It is required for progressive and efficient polymerization of poly(A) tails at the 3′ ends of eukaryotic transcripts and controls poly(A) tail size to about 250 nt. At steady state, the protein is localized in the nucleus, whereas a different poly(A) binding protein is localized in the cytoplasm.

The gene contains a GCG trinucleotide repeat at the 5′ end of the coding region; expansion from 6 to 8–13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD). Related pseudogenes exist on chromosomes 19 and X. Read-through transcription also occurs between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.