Thermo Fisher Scientific PABPN1 Polyclonal Antibody
Thermo Fisher Scientific의 PABPN1 Polyclonal Antibody는 인간 PABPN1 단백질(1–50번 잔기)을 인식하는 Rabbit IgG 항체입니다. WB, IHC, IP 등 다양한 응용에 적합하며, 액상 형태로 제공되고 4°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 1 and 50 of human Poly(A) Binding Protein, Nuclear 1 (PABPN1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer (pH 6.0) is recommended for FFPE tissue sections.
- Based on 100% sequence identity, this antibody is predicted to react with Bovine.
Target Information
This gene encodes an abundant nuclear protein that binds with high affinity to nascent poly(A) tails. It is required for progressive and efficient polymerization of poly(A) tails at the 3′ ends of eukaryotic transcripts and controls poly(A) tail size to about 250 nt. At steady state, the protein is localized in the nucleus, whereas a different poly(A) binding protein is localized in the cytoplasm.
The gene contains a GCG trinucleotide repeat at the 5′ end of the coding region; expansion from 6 to 8–13 copies leads to autosomal dominant oculopharyngeal muscular dystrophy (OPMD). Related pseudogenes exist on chromosomes 19 and X. Read-through transcription also occurs between this gene and the neighboring upstream BCL2-like 2 (BCL2L2) gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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