Thermo Fisher Scientific GRK1 Monoclonal Antibody (4E9)
GRK1 단백질을 인식하는 Mouse monoclonal antibody (Clone 4E9)로, Western blot과 ELISA에 적합합니다. 인간 GRK1에 특이적으로 반응하며 액상 형태로 제공됩니다. 연구용으로만 사용되며 -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4E9 |
| Immunogen | GRK1 (NP_002920.1, 51–150 a.a.) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
RDSLSLEFES VCLEQPIGKK LFQQFLQSAE KHLPALELWK DIEDYDTADN DLQPQKAQTI LAQYLDPQAK LFCSFLDEGI VAKFKEGPVE IQDGLFQPLL
Target Information
GRK1 is a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinases.
It mediates rapid desensitization of rod photoreceptors to light by catalyzing phosphorylation of the visual pigment rhodopsin, leading to its deactivation.
Defects in GRK1 cause Oguchi disease 2 (stationary night blindness Oguchi type-2).
GRK1 can be phosphorylated by PKA, reducing its ability to phosphorylate rhodopsin in vitro.
Phosphorylation by PKA in vivo is speculated to occur in the dark when cAMP levels are elevated in photoreceptor cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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