Thermo Fisher Scientific PRPF18 Polyclonal Antibody
PRPF18 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체입니다. Western blot과 Immunocytochemistry에 최적화되어 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 40 kDa 단백질 검출, PBS/glycerol 완충액에 보관됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 223–268 of human PRPF18 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553871 |
Product Specific Information
- Detects endogenous PRPF18 protein at approximately 40 kDa.
- Purity >95% by SDS-PAGE.
Target Information
PRPF18 (pre-mRNA-splicing factor 18), also known as HPRP18, is a 342 amino acid protein localized to nuclear speckles and involved in the second step of pre-mRNA splicing.
It belongs to the PRP18 family and contains seven WD repeats. Two alternatively spliced isoforms are encoded by a gene located on human chromosome 10p13.
Chromosome 10 includes over 800 genes and 135 million nucleotides. The PTEN tumor suppressor gene is located on chromosome 10, and its defects are associated with Cowden syndrome and other disorders such as Cockayne syndrome, tetrahydrobiopterin deficiency, and trisomy 10.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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