Thermo Fisher Scientific NO66 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000

Product Specifications

Product Specific Information

• Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates Lys-4 (H3K4me) and Lys-36 (H3K36me) of histone H3, thereby playing a central role in histone code regulation. Preferentially demethylates trimethylated H3 Lys-4 (H3K4me3) and monomethylated H3 Lys-4 (H3K4me1), with weaker activity on dimethylated H3 Lys-36 (H3K36me2). Also catalyzes hydroxylation of 60S ribosomal protein L8 on His-216. Acts as a regulator of osteoblast differentiation via interaction with SP7/OSX, inhibiting SP7/OSX-mediated promoter activation. May play roles in ribosome biogenesis, heterochromatin remodeling, and MYC-induced transcriptional activation.
[Source: UniProt]

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.