Thermo Fisher Scientific ITM2B Polyclonal Antibody
ITM2B 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용 가능. 인간, 마우스, 랫트 반응성. 고순도 항원 친화 크로마토그래피 정제. 알츠하이머 및 신경퇴행성 질환 연구에 적합.
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- PA531441
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Thermo Fisher Scientific ITM2B Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 15–264 of Human ITM2B |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.81 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2548915 |
Product Specific Information
- Recommended positive controls: HepG2, HCT116, mouse brain, rat brain
- Predicted reactivity: Mouse (95%), Rat (96%), Pig (95%), Sheep (96%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (96%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease.
This gene encodes a transmembrane protein processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide that inhibits beta-amyloid deposition.
Mutations extending the C-terminal end of the encoded protein, increasing the size of the secreted peptide, are associated with familial British dementia and familial Danish dementia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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