Thermo Fisher Scientific GLRB Monoclonal Antibody (3B8A8)
GLRB 단백질을 인식하는 마우스 모노클로날 항체로, Western blot, ICC/IF, Flow cytometry, ELISA 등 다양한 응용에 적합합니다. 단백질 G로 정제된 액상 형태이며, PBS에 0.05% sodium azide를 포함합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3B8A8 |
| Immunogen | Purified recombinant fragment of human GLRB (AA: extra 23–160) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787364 |
Product Specific Information
MA5-31741 has been tested in indirect ELISA.
Target Information
In the central nervous system (CNS), glycine-mediated inhibitory neurotransmission is essential to voluntary motor control and reflex responses. Glycine binds to glycine receptors (GlyR) in the postsynaptic neuronal membranes. GlyR, gamma-aminobutyric acid, serotonin, and acetylcholine comprise an evolutionarily conserved superfamily of ligand-gated ion channels.
The pentameric subunit structure of GlyR consists of two types of glycosylated membrane proteins (alpha1 through alpha4 and beta) and an associated peripheral membrane protein, which together form a chloride-selective ion channel.
In humans, the composition of the pentamer changes from alpha2 subunits in the fetal CNS to alpha1 and beta subunits in the adult CNS. Fast potentiation of GlyR by intracellular Ca²⁺ in the brainstem and midbrain indicates an important role for Ca²⁺ in modulation of glycinergic synapses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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