Thermo Fisher Scientific CMKLR1 Polyclonal Antibody
CMKLR1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, ICC 등 다양한 응용에 사용 가능. 인간 시료 반응성. Affinity chromatography로 정제되었으며, PBS/glycerol buffer에 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CMKLR1 (Accession Q99788), corresponding to amino acid residues F229–L279 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850425 |
Product Specific Information
This antibody detects endogenous levels of total CMKLR1.
Target Information
Chemokine-like receptor 1 (CMKLR1) is a receptor for the chemoattractant adipokine chemerin (RARRES2) and for the omega-3 fatty acid-derived molecule resolvin E1.
Interaction with RARRES2 activates intracellular signaling molecules such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK, and PI3K, leading to effects like immune response reduction, adipogenesis enhancement, and angiogenesis.
Resolvin E1 down-regulates cytokine production in macrophages by reducing activation of MAPK1/3 (ERK1/2) and NF-kappa-B.
CMKLR1 positively regulates adipogenesis and adipocyte metabolism and acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR, SIVSM62A) and a primary HIV-1 strain (92UG024-2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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