Thermo Fisher Scientific Phospho-PLCG2 (Tyr753) Polyclonal Antibody
Rabbit polyclonal antibody recognizing phosphorylated PLCG2 (Tyr753). Validated for WB and IHC-P. Supplied as liquid, unconjugated form at 1 mg/mL. Suitable for research use in signal transduction and phospholipase C pathway studies.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human PLCG2 around the phosphorylation site of Tyr753 (S-L-YP-D-V) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2554846 |
Target Information
Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in receptor-mediated signal transduction by generating two second messengers, inositol 1,4,5-triphosphate and diacylglycerol, from phosphatidylinositol 4,5-bisphosphate.
There are multiple mammalian PLC isozymes, including PLCβ1, PLCβ2, PLCβ3, PLCβ4, PLCγ1, PLCγ2, PLCδ1, PLCδ2, and PLCε.
PLCδ1 acts as a calcium signal amplifier and is activated by an atypical GTP-binding protein. It also functions as an effector for GTP-binding protein transglutaminase II-mediated oxytocin receptor and α1B-adrenoreceptor signaling. Mouse PLCδ1 is highly expressed in brain, heart, lung, and testis.
PLCδ has been found abnormally accumulated in brains of Alzheimer’s disease patients, suggesting a possible pathological role. PLCδ2 is markedly expressed in type II intestinal metaplasia and adenocarcinoma, and its expression may serve as a potential marker for gastric malignant transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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